Immunology:
Putting the Squeeze on Asthma Innately

Microbiology:
New Center Wields Genome Data to Battle Bugs
Bioengineering:
Researchers Build Brave New Nano World
Ophthalmology:
Sights Set on Partial Corneal Transplants
Medical Education:
Medical College Association Pushes Teaching-Hospital Budget Relief
New Books:
The Autumn Bookshelf



How Papillomavirus Proteins Brew Genetic Errors, Cancer

Paper Suggests Why Hens Don't Have Teeth

Residency Directors and Managed Care Medical Directors Agree on Training

Is the Food Pyramid Healthy?



New Full and Named Professorships

Student Orientation 2000

Outreach

In Memoriam

Honors and Advances

News Brief

On The Threshold Events

China Journey Finds Integration of Eastern, Western Medical Practice and Education

Nonprofit Links Health Professionals in Developing World

Front Page

BULLETIN

New Appointments to Full and Named Professorships

These faculty members were appointed to a full professorship in June and July.

Peter Berman
Professor of Population and International Health
Harvard School of Public Health
Berman is an economist specializing in health systems research in developing countries and has devised widely used methods for measuring national health expenditure (National Health Accounts). He also studies the role of private health care in lower income countries and is working on strategies to help national authorities manage this better for health and equity. He directs the International Health Systems Group at the Harvard School of Public Health, which is active in research, policy advisement, and training to improve health systems worldwide.

Stephen Calderwood
Professor of Medicine
Massachusetts General Hospital
Calderwood is chief of the Division of Infectious Diseases at Massachusetts General Hospital. His research focuses on the molecular pathogenesis of bacterial infections and the development of vaccines and vaccine vectors for infections at mucosal surfaces. He recently received funding from the National Institutes of Health to develop a program of international collaboration in infectious disease research with investigators in Bangladesh to fight cholera.

Stephen Goldring
Professor of Medicine
Beth Israel Deaconess Medical Center
Goldring is the chief of Rheumatology at Beth Israel Deaconess Medical Center and the director of research at New England Baptist Bone and Joint Institute at the Harvard Institutes of Medicine. He is a senior fellow in the Cannon Society and codirects the musculoskeletal pathophysiology second-year course at HMS. His research has focused on the mechanisms of bone loss in inflammatory disorders such as rheumatoid arthritis and on the skeletal effects of orthopedic implant biomaterials.

Robert A. Levine
Professor of Medicine
Massachusetts General Hospital
Levine is a cardiologist specializing in noninvasive imaging. His recognition of the saddle shape of the mitral valve led to redefinition of mitral valve prolapse with greatly increased specificity. He directs research efforts developing and applying advanced ultrasound techniques to quantify valvular heart disease and translate mechanistic understanding into improved therapeutic approaches, with current focus on ischemic mitral regurgitation and the genetic basis of mitral valve prolapse.

Joseph Majzoub
Professor of Pediatrics
Children's Hospital
Majzoub is chief of the Division of Endocrinology at Children's Hospital. His major research interests include the mechanisms and consequences of responses to stress, including how fetal responses to intrauterine stress affect fetal maturation and the timing of birth.

Alvin Poussaint
Professor of Psychiatry
Judge Baker Children's Center
Poussaint is director of the media center at Judge Baker Children's Center and has been faculty associate dean for student affairs at HMS since 1969. He is also director of the HMS Office for Recruitment and Multicultural Affairs. Poussaint recently coauthored Lay My Burden Down: Unraveling Suicide and the Mental Health Crisis Among African-Americans (see New Books). His research interests have ranged from treatment of childhood enuresis to studies of civil rights workers and the impact of media on children and adolescents.

Wing Hung Wong
Professor of Computational Biology
Harvard School of Public Health
Wong was formerly a professor of statistics and human genetics at UCLA. He is interested in the application of mathematics, statistics, and computation to biology and medicine. Current research topics include the analysis of gene expression microarray data, computational discovery of polymorphic markers from DNA sequence databases, and protein-fold modeling and recognition.

This HMS faculty member was appointed to an endowed professorship in July.

Nancy Harris
Austin L. Vickery Professor of Pathology
Massachusetts General Hospital
Harris is the director of pathology training programs at Massachusetts General Hospital. Her clinical and research interests lie in the area of lymphoma diagnosis and classification. She was the lead author of a new lymphoma classification (the R.E.A.L. classification) and is currently a leader in developing a new World Health Organization classification of hematologic malignancies to facilitate diagnosis, treatment, and research.


First-years (l to r) Sarvenaz Zand, Joseph Ladapo, and Liu (Lewis) Shi spent the week before they began their first semester at HMS by helping out at Harvard Pediatric Health Services as part of the First-year Urban Neighborhood Campaign (FUNC). Established in 1998, the program seeks to encourage community service while at HMS. During the past two years, FUNC has worked with more than 16 community organizations in Boston and involved more than 120 medical students. This year's more than 40 first-year students volunteered at the American Cancer Society, Boston Living Center, Brookside Community Health Center, the Chinatown Afterschool Program, Harvard Pediatric Health Services, Health for the City, Hepatitis B Initiative, and the Home for Little Wanderers. Photo by Liza Green


In Memoriam

Hermann Lisco, retired HMS associate professor of anatomy and former associate dean of the Faculty of Medicine for student affairs, died August 14. He was 89.

Born in Germany and a graduate of the University of Berlin, Lisco left his native country to escape the Holocaust and in 1940 joined the HMS faculty.

An experimental pathologist in the fields of cancer research and radiation, he began his career at HMS as a member of the Pathology Department. While on a leave of absence, he was part of the Manhattan Project at the University of Chicago, where he studied the biological effects of plutonium on humans.

In 1945 he was summoned to Los Alamos to perform an autopsy on the victim of a nuclear accident. This study of the first person to die from radiation exposure along with eight more who died in two accidents at Los Alamos, were reported in The Acute Radiation Syndrome: A Study of Nine Cases and a Review of the Problem. This was the first publication on the effects of radiation exposure on humans.

Before returning to HMS in 1962, Lisco continued to study radiation and cancer for the Atomic Energy Commission and served as scientific secretary to a United Nations panel that published a landmark report on the effects of radiation on the environment and humans.

Lisco was appointed assistant dean of students in 1967, shortly before becoming the associate dean. Though he retired in 1981, his presence at HMS continued until just before his death.

He is survived by his wife, Elisabeth; a son, Tom of Arlington; two daughters, Karen Kosman of Brooklyn, N.Y. and Barbara Lewis of Short Hills, N.J.; seven grandchildren and five great-grandchildren.

A memorial service will be held this fall.

Henry Altman, HMS assistant clinical professor of psychiatry at Beth Israel Deaconess Medical Center, where he served for more than 40 years, died June 26 at the age of 74.

Altman received his BA from Sarah Lawrence College and his MD from Boston University. He first came to Beth Israel as a fellow in psychiatry in 1957 before joining the HMS faculty in 1960.

He served as the residency training director of the psychiatry department at the hospital, which peers rated one of the best training programs in Greater Boston. From 1973 to 1978, he was a pioneer in the development of peer review for the American Psychiatric Association.

Altman was a fellow of the American College of Psychiatry and the American Psychiatric Association. He was a past president of the Massachusetts Psychiatric Society and former chairman of the board of the Boston Psychoanalytic Society.

He is survived by his wife, Dorothy of Cambridge; three daughters, Alison of Cambridge, Debby Kilday of Watertown, and Susan of Albuquerque, N.M.; and two grandchildren.

Guillermo Sanchez, HMS assistant clinical professor of medicine who was associated with Massachusetts General Hospital for 50 years, died Aug. 17 at the age of 75.

Born in Guatemala City, Guatemala, Sanchez graduated from Harvard College and HMS. Following his residency at MGH, he served in the U.S. Army Medical Corps in South Korea from 1955 to 1957.

Sanchez, who was fluent in five languages, spent from 1972 to 1973 in Africa as a consultant and chief of gastroenterology at the Mulago Hospital in Kampala, Uganda, and as a consultant for Kenyatta National Hospital in Kenya.

An ardent medical historian, he published many articles, including papers on the early history of anesthesia. Other subjects of his historical research included the French physician who created the guillotine, the medical history of Percy Bysshe Shelley, and Boston Corbett, who killed John Wilkes Booth.

Sanchez was president of the overseas board of overseers for El Universidad del Valle de Guatemala, where he helped raise funds to create Latin America's first endowed chair in archaeology. He was also the past president of the Roxbury Clinical Records Club, a physicians' social group, and a member of the Club of Odd Volumes, a Beacon Hill literary society.

He is survived by his wife, Sylvia; three sons, Pedro of Wayland, Juan of Wellesley, and Miguel of London; four daughters, Maria and Isa of Cambridge, Lucia of Redwood City, Calif., and Felicia of Jamaica Plain; a brother, Roberto, and sister, Isa Selle, both of Guatemala City; and 10 grandchildren.

Thornton Brown, professor emeritus of orthopedic surgery at Massachusetts General Hospital, died July 4. He was 86.

Brown studied as an undergraduate at Harvard College and received his MD from HMS.

He joined the medical staff at MGH in 1948, after serving in the Navy Medical Corps during WW II. In addition to his teaching at HMS, he was a consultant at Milton Hospital.

Brown was the former editor of the Journal of Bone and Joint Surgery.

He is survived by a son, Edward of Milton; three daughters, Marian Hazzard of Grafton, Nina Brown of Brookline, and Sarah Brown of Amherst; a brother, Lloyd of Blue Hill, Maine; a sister, Ruth Ernst of Harvard; and eight grandchildren.

Eugene Courtiss, HMS associate clinical professor of surgery at Massachusetts General Hospital, died July 11 at the age of 70.

A Boston native, Courtiss was chief of plastic surgery at Newton-Wellesley Hospital from 1969 to 1993, as well as a consultant at MGH.

During his career he had been president of the American Society for Aesthetic Plastic Surgery, director of the American Board of Plastic Surgery, and associate editor of Plastic and Reconstructive Surgery. Courtiss was the editor of five books and a visiting professor at more than 30 universities.

He is survived by his wife, Barbie; a daughter, Linda Rheingold of Chestnut Hill; a brother, Dick of Duxbury; and three grandchildren.


Welcome to the Quad

On August 31, Joseph Martin, dean of the Faculty of Medicine, welcomed the Class of 2004 to HMS during a speech he gave from the steps of Gordon Hall (Photo above by Steve Gilbert). Earlier in the day, new medical students were presented with their white coats during ceremonies held by each society. Below, Lauren Canter of the Holmes Society checks out the fit of her first white coat.

New PhD students in the program in virology (below, l to r) John Bowman, Andrew Barbera, and Matthew DiVisconte listen to speakers at the Sept. 6 orientation for students in the Division of Medical Sciences. Seated in front of them is Zarine Balsara, a student in the immunology program.


Honors and Advances

Chief of community clinical services and director of medical education at McLean Hospital, Paul Barreira has received the Lilo McMillan Award from the Massachusetts Department of Mental Health (DMH). A former DMH deputy commissioner of clinical and professional services, Barreira was honored at the third annual DMH Commissioner's Reception.

Harry Levinson, HMS clinical professor emeritus of psychology in the Department of Psychiatry at the Massachusetts Mental Health Center, received the 2000 Gold Medal for Life Achievement in the Application of Psychology from the American Psychological Foundation. Levinson, who was presented with the award in early August, was recognized for his influence in the creation of the subfield of business and organizational psychology. He is considered the founder of psychoanalytic organizational psychology.

The Society for Photobiology awarded Micheline Mathews-Roth, HMS associate professor of medicine at Brigham and Women's Hospital, with its Lifetime Achievement Award at its annual meeting in July. Currently Mathews-Roth is concentrating on developing gene therapy as a potential cure for erythropoietic protoporphyria, since standard beta-carotene treatment, although effective in preventing the development of symptoms, has no effect on the disease's cause.

Thomas Kupper, the Thomas B. Fitzpatrick professor of dermatology, has been appointed the first chair of the newly established Department of Dermatology at Brigham and Women's Hospital. Formerly a division of the Department of Medicine at Brigham and Women's, the department is the principal site of the NIH-funded Skin Disease Research Center and oversees the Center for Cutaneous Oncology at the Dana–Farber Cancer Institute.

One of the first Fulbright Alumni Initiatives Awards has been given to Byron Good, HMS professor of medical anthropology in the Department of Social Medicine. Good's proposal for a collaborative program of research and exchange on the social aspects of drug use and infectious diseases with the medical faculty of Gadjah Mada University in Indonesia was one of only 21 selected from the 550 proposals submitted by former Fulbright scholars.

At the end of October, the 2000 George W. Teuscher Golden Pen Award will be presented to two current and two former HSDM researchers for their article "Periodontitis in the Child and Adolescent" that appeared in the May–June 1999 Journal of Dentistry for Children. Nawarat Wara-aswapati, former instructor in periodontology; T. Howard Howell, dean for dental education and professor of periodontology; Howard Needleman, former clinical professor of growth and development (pediatric dentistry); and Nadeem Karimbux, assistant professor of periodontology, are being honored with the award, which is sponsored by the American Society of Dentistry for Children, for journalistic excellence in the dental field.

Christopher Rudd, HMS associate professor of pathology at the Dana–Farber Cancer Institute, has been awarded a Wellcome Principal Research Fellowship, the largest and most prestigious award given by the Wellcome Trust. The five-year, $5.2 million award will support Rudd's research on immune cell signaling and function.

Katia Apollon, a 2000 graduate of Brigham and Women's Hospital–Massachusetts General Hospital Integrated Training Program in Obstetrics and Gynecology, received the annual Humanism Award given to a graduating resident. Apollon is a clinical fellow in obstetrics, gynecology and reproductive biology at Brigham and Women's.

Seventh-year MD–PhD students Alex Carter and Abraha Taddese were named the two winners of the 2000–2001 Award for Medical Journalism from the National Medical Association. The award recognizes journalistic excellence as well as overall academic achievement and leadership. Each will receive a $2,500 stipend.

The Massachusetts Association of Behavioral Health Systems has elected as its president Michele Gougeon, executive vice president and chief operating officer at McLean Hospital. The association is the only trade organization in the state whose main purpose is to focus on inpatient mental health and substance abuse issues. Gougeon is an HMS lecturer on psychiatry.

The Massachusetts chapter of the Lupus Foundation of America elected Lisa Fitzgerald, HMS instructor in medicine and a rheumatologist at Beth Israel Deaconess Medical Center and New England Baptist Hospital, as one of its co-presidents and Andrea Schneebaum, HMS clinical instructor in medicine at the Lahey Clinic, as vice president. Schneebaum also chairs the medical advisory board. Cofounder of the Massachusetts chapter of the organization Peter Schur has been re-elected to its board of directors. Schur is HMS professor of medicine and director of the lupus clinic at Brigham and Women's Hospital.

The Northeast National Association of Minority Medical Educators selected Rhondee Benjamin-Johnson '02 as one of its LeGrand Newman Scholars for 2000. The $1,000 scholarship recognizes Benjamin-Johnson's academic achievement and service to the community.

Walter Lech '01 and Rey Ramos '01 have been named 2000 Arthur Ashe Program in AIDS Care fellows. Lech and Ramos will participate in a four-week multidisciplinary training program at the Harvard AIDS Institute in October and each will receive a $6,000 stipend. The award recognizes their potential for responsible roles in HIV-related care and research. Ramos has also been named a Program in Violence Prevention for Minority Medical Students fellow. As a fellow, he will participate in an eight-week program at the Centers for Disease Control and Prevention, which cosponsors the fellowship that teaches medical students to understand and address violence from a public health perspective. Ramos will receive a $5,000 stipend as part of his fellowship.

MD–PhD students Bradley Carthon '04 and Michelle Lee '03 have been selected as United Negro College Fund/Merck Graduate Science Research Dissertation fellows. Fellows receive stipends of up to $30,000 and their departments receive grants of up to $10,000. The fellowship is aimed at increasing the pool of well-qualified African-American research scientists in the biomedical sciences.

Marc Halfon, a postdoc in the lab of Alan Michelson, HMS associate professor of medicine at Brigham and Women's Hospital and Howard Hughes Medical Institute investigator, won the award for best poster presentation at the annual meeting of the Society for Developmental Biology held in Boulder, Colo., at the beginning of June. The prize includes a trip to present his work at the next annual meeting of the British Society for Developmental Biology.

At the American Psychiatric Association annual convention, Francis Frankenburg, HMS lecturer on psychiatry and associate director of the McLean Hospital laboratory for the study of adult development, was honored for her more than 20 years in psychiatry. Frankenburg was presented with the National Alliance for the Mentally Ill Exemplary Psychiatrist Award.

Rashi Fein, HMS professor emeritus of the economics of medicine in the Department of Social Medicine, was awarded a Lifetime Achievement Award by Health Care For All at the organization's community leadership awards ceremony.

At a ceremony in London, the Royal Society for the Promotion of Health recognized John Spengler, the Akira Yamaguchi professor of environmental health and habitation at HSPH, for his long career of improving urban health and indoor air quality. The society awarded him the J.W. Starkey Silver Medal, which is given each year to an individual who has made outstanding contributions to promoting better health.

Head of the Consolidated Department of Psychiatry at McLean Hospital, Joseph Coyle has been elected president of the American College of Neuropsychopharmacology. He is the Eben S. Draper professor of psychiatry.

William Cohn, HMS instructor in surgery at Beth Israel Deaconess Medical Center, received the 2000 Distinguished Inventor Award from the Intellectual Property Owners Association. Cohn was recognized at a June 28 ceremony in Washington, D.C., for inventing the Cohn Cardiac Stabilizer, a device and method that allows coronary artery bypass surgery on a beating heart without the use of a heart–lung machine.

The Academy for Health Services Research and Health Policy honored HSPH faculty member Robert Blendon, professor of health policy and management, at a June 27 ceremony in Los Angeles. Blendon received the Association of Health Services Distinguished Investigator Award for Lifetime Achievement.

News Brief

The William F. Milton Fund is accepting applications from faculty members to support research that promotes the physical and material welfare of the human race or investigates and determines the value and importance of a discovery or invention. The deadline is Oct. 15. For an application and more information contact Kemith Leblanc at 432-2663 or e-mail kemith_leblanc@hms. harvard.edu.


On the Threshold: Harvard Medicine at the Millennium

Dean Joseph Martin's millennial celebration continues with these upcoming events. For more information, visit the website.

September 20

Future Research Trends/Opportunities in Aging
John Rowe, president and CEO of Mt. Sinai–NYU Medical Center and Health System, and Richard Hodes, director of the National Institute on Aging, speak about what's on the horizon in the field of aging research.
4:00-6:00 pm, TMEC Amphitheater, HMS

September 22

Infectious Disease: Challenges and New Strategies for Control
Speakers from HMS, HSPH, Massachusetts General Hospital, and the CDC will discuss TB, malaria, AIDS, the Ebola virus, and other infectious diseases and what's new in the fight against them.
1:00-6:00 pm, TMEC Amphitheater, HMS

October 3

Nuclear Shuttling: Pathways to Vital Functions in Health and Disease
This Mallinckrodt Foundation–sponsored symposium hosts speakers from HMS, the Scripps Research Institute, the University of Pennsylvania, Columbia University, and Rockefeller University.
9:00 am-1:00 pm, Enders Auditorium, Children's Hospital

October 27

How the Body Works—Genomes, Development, and Disease
In two separate sessions, Harvard faculty and speakers from Johns Hopkins and Columbia will address early embryonic development, patterning mechanisms, limb development, and brain development and function.
1:00-6:00 pm, TMEC Amphitheater, HMS

HMS State of the School Address

Joseph Martin, dean of the Faculty of Medicine, will give the annual HMS State of the School Address in the Tosteson Medical Education Center amphitheater at 12:15 p.m. on Sept. 26.