Genetics:
Genetic Link Discovered for Late Onset Alzheimer's

Pathology 1:
Molecular Bureaucrat Tied to Replication Approval Process
Cancer Research:
Endostatin Beads Pack Therapeutic Punch
Pathology 2:
Molecular Agent Prepares Immune Forces



Role Found for Protein in Kidney Disease

Marriage of Brain Receptors Breeds Synapses

Few Links Shown Between Iron Level, Heart Disease Risk

Transplanted Fetal Nerve Cells Thrive in Brain



Full Professors

Quad Bulletin Now Online

In Memoriam:
Milford Schulz

Quad Histopathology Facility One of Cancer Center Cores

Honors and Advances

Trading Places: Students Give Teachers Lesson on Clerkships

Front Page

BULLETIN

New Appointments to Full and Named Professorships at HMS and HSPH

These faculty members were appointed to a full professorship in October and November.

Atul Bhan
Professor of Pathology
Massachusetts General Hospital
Bhan is director of the Immuno-pathology Unit and an associate director of the Center for the Study of Inflammatory Bowel Disease, both at Massachusetts General Hospital. His clinical responsibilities include diagnostic immunoperoxidase studies and liver transplantation pathology. Bhan is also participating in a clinical trial to define long-term treatment of chronic hepatitis C. His current research interests are mucosal immunology, the pathogenesis of inflammatory bowel disease, and experimental models of intestinal inflammation.

Alan D'Andrea
Professor of Pediatrics
Dana–Farber Cancer Institute
D'Andrea is the director of the Comprehensive Fanconi Anemia Center at the Dana–Farber Cancer Institute and Children's Hospital. His research interests include the signal transduction pathways of the erythropoietin receptor and the molecular pathogenesis of Fanconi anemia. His clinical interests include genetic screening of families with cancer susceptibility and gene therapy for bone marrow failure syndromes.

David Jimerson
Professor of Psychiatry
Beth Israel Deaconess Medical Center
Jimerson is a psychiatrist and director of research in the Department of Psychiatry at Beth Israel Deaconess Medical Center. His clinical investigations focus primarily on the psychobiology of eating disorders and related aspects of mood disorders.

Michael Hughes
Professor of Biostatistics
Harvard School of Public Health
Hughes directs the Statistical and Data Management Center for the Pediatric AIDS Clinical Trials Group. This group evaluates the majority of U.S. clinical trials of treatments for HIV-infected children and adolescents and interventions for preventing mother-to-child transmission of HIV. In addition to his HIV research interests, Hughes's work focuses on statistical methodology applied to the design and analysis of clinical trials. He is a leader in statistical and applied research in the evaluation of surrogate markers.

Barbara Kahn
Professor of Medicine
Beth Israel Deaconess Medical Center
Kahn is chief of the Diabetes Unit at Beth Israel Deaconess Medical Center and associate director of the Boston Obesity Nutrition Research Center. Her research focuses on the cellular and molecular mechanisms for insulin resistance in obesity and diabetes. She investigates the regulation of glucose transport and insulin signaling in altered metabolic and nutritional states, using transgenic and gene knockout mouse models as well as human studies. Recently her research has also focused on the insulin-sensitizing effects of leptin. Her goal is to discover new approaches to prevent or ameliorate Type II diabetes.

William Tomford
Professor of Orthopedic Surgery
Massachusetts General Hospital
Tomford is an orthopedist with a clinical interest in bone and cartilage transplantation and joint replacement. Past president of the American Association of Tissue Banks, his research interests focus on the preservation, sterilization, and incorporation of musculoskeletal allografts. At Massachusetts General Hospital, he helped develop the Bone Bank and the Orthopedic Oncology Program.

Junying Yuan
Professor of Cell Biology
Harvard Medical School
Yuan's research focuses on the mechanism of cell death. Her work established caspases, a family of cysteine proteases, as the critical regulators of mammalian apoptosis. Her recent work centers on the signal transduction mechanisms that lead to the activation of caspases and other mediators of physiological and pathological cell death.

These HMS faculty members were appointed to an endowed professorship in October.

Lawrence Cohn
Virginia and James Hubbard Professor of Cardiac Surgery
Brigham and Women's Hospital
Cohn has been chief of cardiac surgery at Brigham and Women's Hospital since 1987 and a full professor of surgery since 1980. He has been director of the Thoracic Surgical Training Program at Brigham and Women's Hospital and Children's Hospital and has trained more than 100 residents and fellows including approximately 15 surgeons who have gone on to become division chiefs. His clinical interests are reconstructive valve surgery, adult congenital heart surgery, and thoracic aortic pathology. He has been a clinical research leader in the evaluation of outcomes of valvular heart surgery. He also has directed the cardiac surgical laboratory at HMS, which has a long interest in myocardial protection, cardiac transplantation, and angiogenesis. He is past president of the American Association for Thoracic Surgery and the American College of Chest Physicians.

Stuart Orkin
David G. Nathan Professor of Pediatrics
Dana–Farber Cancer Institute
Orkin, formerly the Leland Fikes Professor of Pediatric Medicine at HMS, is a pediatric hematologist–oncologist and Howard Hughes Medical Institute investigator at Children's Hospital. He was recently appointed chair of the Department of Pediatric Oncology at the Dana–Farber Cancer Institute. His research interests focus on the molecular basis of differentiation within the blood and vascular systems, stem cell biology, and the normal functions of cancer-associated genes.

J. Wayne Streilein
Charles L. Schepens Professor of Ophthalmology
Schepens Eye Research Institute
Streilein is an immunologist who has pioneered the study of ocular immune privilege. His research has contributed to the understanding of the pathogenesis of immune rejection of corneal and retinal transplants and has illuminated the molecular basis for ocular inflammation. Since 1993 he has served as director of research at the Schepens Eye Research Institute. In 1995 Streilein succeeded Charles Schepens, who was the founder of the institute, as president and chief executive officer.

Moritz Ziegler
Robert E. Gross Professor of Pediatric Surgery
Children's Hospital
Ziegler is the former surgeon in chief of the Children's Hospital Medical Center in Cincinnati. His basic research interests include the immunobiology of neuroblastoma, and his clinical interests have focused on the management of complex Hirsch-sprung's disease and short bowel syndrome. As surgeon in chief at Children's Hospital, he has focused on organizational leadership strategies that enhance physician productivity.

Quad Bulletin Now Online

The HMS Quad Bulletin, the weekly e-mail of events happening on the Quad, is now available to the entire HMS community through the eCommons website (ecommons.med. harvard.edu). At the site, it's listed as a resource under News and Events. Or it can be viewed by going directly to www.hms.harvard. edu/news/quad.html.

In Memoriam

Milford Schulz, HMS professor emeritus of radiation therapy at Massachusetts General Hospital, died Oct. 22. He was 90

For 25 years he served as chief radiotherapist at MGH. He first came to Harvard in 1940 as an assistant radiologist at Harvard's Huntington Memorial Hospital for Cancer Research. In 1942, when the hospital became part of MGH, he joined the staff of MGH as a radiologist.

Regarded by his contemporaries as one of the outstanding radiotherapists in the country, Schulz was a pioneer in the use of supervoltage therapy for the treatment of deep-seated tumors. Particularly significant were his contributions to the treatment of tumors of the nasopharynx and larynx and of carcinoma of the lung.

Schulz was a past president of the American Radium Society, past president of the New England Roentgen Ray Society, and past chancellor of the American College of Radiology.

He is survived by his daughter, Cathy Allen of Belmont.

Quad Histopathology Facility One of Cancer Center Cores

The Rodent Histopathology Core, one of the core facilities that make up the Dana–Farber/Harvard Cancer Center, which were described in the last Focus, is located in the Goldenson Building on the Quad. A satellite site is located at the Dana–Farber Cancer Institute.

Honors and Advances

Lewis Lipsitz, HMS professor of medicine at the Hebrew Rehabilitation Center for Aged, has been named chief of the Division of Gerontology at Beth Israel Deaconess Medical Center.

The Association of American Medical Colleges has selected Jim Hammel, HMS '02, as the Herbert W. Nickens, MD Minority Medical Student Scholar. The award recognizes Hammel's academic achievements and leadership in contri-buting to the elimination of inequalities in medical education and health care.

The National Medical Association has named Jamal Harris, HMS '03, as one of six winners of its 2000–2001 Merit Awards. The prestigious award includes a $2,250 stipend.

Erica Marsh, HMS '01, received the Franklin C. McLean Scholarship from National Medical Fellowships. The honor includes a certificate of merit and a $3,000 cash prize.

HMS assistant professor of cell biology Randall King recently received a Damon Runyon Scholar Award. The award supports the development of outstanding biomedical scientists as independent investigators in the cancer field by aiding their research with a grant of $100,000 per year for three years.

The American Academy of Arts and Sciences inducted David Clapham, Howard Hughes investigator and HMS professor of neurobiology at Children's Hospital, into its membership at a ceremony in October. Clapham was selected for his seminal contributions to understanding the structure and function of G protein-gated K+ channels.

The Global Congress of Gynecologic Endoscopy of the American Association of Gynecologic Laparoscopists awarded the Golden Laparoscope to Neeraj Kohli, HMS instructor in obstetrics, gynecology and reproductive biology at Mount Auburn Hospital. Kohli, who is codirector of the Division of Urogynecology and Pelvic Reconstructive Surgery, received the award for his video "Tension-Free Vaginal Tape Pubovaginal Sling," co-authored with John R. Miklos.

Secretary of Health and Human Services Donna Shalala has named Joan Reede, HMS associate dean for faculty development and diversity, to the advisory council for minority health issues. The council advises Shalala on national minority health issues, policies, and programs, geared to eliminating racial and ethnic disparities in health.

HMS faculty members JudyAnn Bigby, associate professor of medicine at Brigham and Women's Hospital, and Henrietta Robin Barnes, assistant professor of medicine at Cambridge Hospital, received the 2000 Betty Ford Award from the Association for Medical Education and Research in Substance Abuse. They were honored for their "contributions to the development of health care professionals who are committed to educating colleagues and students about caring for patients with alcohol and illict drug–related problems."

The American Association for the Advancement of Science will award the distinction of fellow to member Gerhard Wagner, the Elkan Blout professor of biological chemistry and molecular pharmacology at HMS, during its annual meeting in February. Members elevated to the rank of fellow are chosen for their efforts toward advancing science or fostering applications that are deemed scientifically or socially distinguished.

Muriel Gillick, HMS associate professor of medicine, has been appointed physician in chief at the Hebrew Rehabilitation Center for Aged. For the past eight years, she has been a member of the center's medical staff and recently served as chief of the Medical Education Division of the Department of Medicine. Gillick also directs the Geriatric Fellowship Program at HMS.